Unlock the Future of Cancer Therapeutics

At TegMine Therapeutics, we are on a mission to restore futures cut short by cancer. Our advanced O-glycoproteomics platform is pioneering the next generation of cancer-specific therapeutic targets, and we are dedicated to delivering best-in-class therapies for currently untreatable diseases.

We are seeking a highly motivated and skilled Research Associate to join our dynamic team. In this role, you will be instrumental in designing, developing, and optimizing the processes we use to produce therapeutic antibodies. This hands-on laboratory position focuses on protein expression, purification, and biochemical characterization, supporting our therapeutic pipeline from discovery through the early preclinical stages.

Key Responsibilities

Protein Expression: Express recombinant antibodies through transient and stable transfections in mammalian cell lines (e.g., CHO, HEK293)
Protein Purification: Develop and execute multi-step purification strategies using chromatography systems (e.g., ÄKTA), employing techniques like Protein A affinity, ion-exchange (IEX), and size-exclusion chromatography (SEC)
Biochemical & Biophysical Characterization: Characterize purified antibodies using a range of analytical methods, including SDS-PAGE, Western Blot, flow cytometry, ELISA, internalization, in vitro killing, kinetics analysis, HPLC, and UV-Vis spectrophotometry
Data Analysis & Documentation: Document all experimental procedures and results in an electronic lab notebook (ELN). Analyze, interpret, and present data clearly to the project team
Process Optimization: Help develop and refine robust, scalable processes for antibody production and purification, proactively identifying and troubleshooting issues

Required Qualifications

A Master’s degree in Molecular Biology, Biochemistry, Biotechnology, or a related field with 2+ years of industry experience, OR a Bachelor's degree with 4+ years of industry experience
Technical Skills:Proficient in mammalian cell culture and aseptic techniques
Demonstrated expertise in protein purification using chromatography systems
Familiarity with standard analytical techniques for protein characterization (e.g., SDS-PAGE, HPLC, flow cytometry, ELISA)
Personal Attributes:Excellent problem-solving skills, organization and time-management abilities
A collaborative spirit with the ability to work effectively both independently and as part of a team
Clear and effective written and verbal communication skills

We provide a comprehensive compensation and benefits package, including:

Equity in a promising start-up
Comprehensive health coverage
401k & paid time off
Significant opportunities for professional growth and development

If you're passionate about innovation, thrive in a collaborative environment, and want to make a real impact, we’d love to hear from you! TegMine is an equal opportunity employer and does not discriminate based on any legally protected status. To apply, please email us at futures@tegminetx.com.

TegMine Therapeutics, Inc.

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Research Associate - Antibody Discovery and Development